Tool Interpretation Disclaimer
How should we intuitively interpret the use of this tool and the information provided?
Most of the information presented regarding occupational exposures is based on established Job-Exposure Matrices (JEMs), which are widely used in occupational epidemiology (Peters et al., 2010). Narrative descriptions of occupational histories are translated into occupational codes—typically based on the International Standard Classification of Occupations (ISCO)—and then matched with the appropriate JEMs. These matrices link job titles to workplace hazards and provide a systematic method for assessing exposure based on expert judgment, measurement data, or both.
The following JEMs were employed in this tool:
- ALOHA JEM (Skorge et al., 2009)
- Dusts and fibres: mineral dust, organic dust
- Solvents: chlorinated solvents, aromatic solvents, other solvents
- Metals: unspecified metals
- Pesticides: fungicides, herbicides, insecticides
- Other chemicals: gases and fumes
- SYN-JEM (Peters et al., 2016)
- Dusts and fibres: asbestos, quartz
- Metals: chromium VI, nickel
- Other chemicals: benzo[a]pyrene
- OAsJEM (Le Moual et al., 2017)
- 30 agents including high and low molecular weight (HMW/LMW) sensitizers, mites, microbial exposures, irritants, highly reactive chemicals, and biocides
To complement these JEMs, additional literature sources were consulted, including:
- Kongsupon (2021) and Barnes (2021) on hypersensitivity pneumonitis
- Henneberger (2004) on berylliosis
- IARC Monographs for lung carcinogens
- NVAB Report (2019) for asthma and COPD
- Asthma in the Workplace Handbook (2021)
Important Notes
It is important to interpret the exposure-disease information with caution. This tool provides a general, initial overview of risk factors that commonly or more frequently occur in specific occupations. It is meant to serve as a starting point in evaluating whether a disease may be related to one or more occupational exposures.
However, the tool does not capture all possible exposures, and some relevant data may be missing. In some cases, an agent listed in the app might contribute to additional diseases not explicitly reported. Limitations in feasibility, data availability, or matrix precision may lead to omissions or inaccuracies in specific cases.
Despite these limitations, the tool offers substantial guidance and background information that can support healthcare professionals, occupational physicians, and workers in identifying potential links between occupational exposures and health effects. That said, any suspected link must be confirmed through a detailed investigation of the individual’s specific exposure history.
The tool does not imply causality and is not a substitute for a comprehensive occupational health assessment. However, by highlighting key occupational risks, it can serve as a supportive aid, especially when rapid orientation is needed or when initial details may have been missed during case evaluation.
References
- Gutor SS, Miller RF, Blackwell TS, Polosukhin VV. Environmental and occupational bronchiolitis obliterans: new reality. EBioMedicine. 2023 Sep 1; 95.
- Barnes H, Lu J, Glaspole I, Collard HR, Johannson KA. Exposures and associations with clinical phenotypes in hypersensitivity pneumonitis: A scoping review. Respiratory Medicine. 2021 Aug; 184:106444. doi: 10.1016/j.rmed.2021.106444
- Kongsupon N, Walters GI, Sadhra SS. Occupational causes of hypersensitivity pneumonitis: a systematic review and compendium. Occupational Medicine (London). 2021 Oct 1; 71(6–7):255–259.
- Peters S, Vienneau D, Sampri A, Turner MC, Castaño-Vinyals G, Bugge M, Vermeulen R. Occupational exposure assessment tools in Europe: a comprehensive inventory overview. Annals of Work Exposures and Health. 2022 Jun 1; 66(5):671–686.
- Le Moual N, Zock JP, Dumas O, Lytras T, Andersson E, Lillienberg L, Schlünssen V, Benke G, Kromhout H. Update of an occupational asthma-specific job exposure matrix to assess exposure to 30 specific agents. Occupational and Environmental Medicine. 2018 Jul 1; 75(7):507–514.
- Nett RJ, Harvey RR, Cummings KJ. Occupational bronchiolitis: an update. Clinics in Chest Medicine. 2020 Dec 1; 41(4):661–686.
- Peters S, Vermeulen R, Portengen L, et al. SYN-JEM: A Quantitative Job-Exposure Matrix for Five Lung Carcinogens. Annals of Occupational Hygiene. 2016 Aug; 60(7):795–811. doi: 10.1093/annhyg/mew034
- Van Soom M, et al. Achtergronddocument NVAB Richtlijn Astma COPD 2019. https://www.researchgate.net/publication/335619286_Achtergronddocument_NVAB_Richtlijn_Astma_COPD_2019
- Henneberger PK, Goe SK, Miller WE, Doney B, Groce DW. Industries in the United States with airborne beryllium exposure and estimates of the number of current workers potentially exposed. Journal of Occupational and Environmental Hygiene. 2004 Oct 1; 1(10):648–659.